Alcohol-withdrawn animals have a prolonged increase in dopamine D2high receptors, reversed by general anesthesia: relation to relapse?

@article{Seeman2004AlcoholwithdrawnAH,
  title={Alcohol-withdrawn animals have a prolonged increase in dopamine D2high receptors, reversed by general anesthesia: relation to relapse?},
  author={Philip Seeman and Teresa Tallerico and Françoise Ko},
  journal={Synapse},
  year={2004},
  volume={52 2},
  pages={77-83}
}
The biochemical basis for alcohol addiction and relapse is not known. Although ethanol promotes the release of dopamine like other drugs of abuse, many unknown factors remain to be investigated concerning the biochemical abnormalities which persist after ethanol drinking and which contribute to alcohol relapse. Although ethanol withdrawal is associated with enhanced sensitivity to dopamine in animals and humans, only minor changes in the striatal density of dopamine D2 receptors have been found… CONTINUE READING