Alcohol withdrawal: effects of clonidine treatment on sympathetic activity, the renin-aldosterone system, and clinical symptoms.

@article{Manhem1985AlcoholWE,
  title={Alcohol withdrawal: effects of clonidine treatment on sympathetic activity, the renin-aldosterone system, and clinical symptoms.},
  author={Per Manhem and Lars H. Nilsson and Anders Moberg and J. Wadstein and B. H{\"o}kfelt},
  journal={Alcoholism, clinical and experimental research},
  year={1985},
  volume={9 3},
  pages={238-43}
}
Twenty male alcoholics with alcohol withdrawal syndrome were randomized to receive either oral clonidine (3-600 micrograms, six hourly) or oral chlormethiazole (500-1000 mg, six hourly) for 4 days. All subjects were also given oral carbamazepine (200 mg, 12 hourly) throughout the study. Nine subjects given clonidine and eight given chlormethiazole completed the study. Clonidine was as effective as chlormethiazole in suppressing the symptoms and signs of alcohol withdrawal. However, plasma… CONTINUE READING

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