Alcohol versus brush PRK: Visual outcomes and adverse effects

  title={Alcohol versus brush PRK: Visual outcomes and adverse effects},
  author={Rose K Sia and Denise S. Ryan and Richard D. Stutzman and Maximilian Psolka and Michael J. Mines and Melvin E Wagner and Eric D Weber and Keith J. Wroblewski and Kraig S Bower},
  journal={Lasers in Surgery and Medicine},
A smooth corneal surface prior to laser ablation is important in order to achieve a favorable refractive outcome. In this study, we compare PRK outcomes following two commonly used methods of epithelial debridement: Amoils epithelial scrubber (brush) versus 20% ethanol (alcohol). 
Complications and Management in Laser Refractive Surface Ablation (SA)
This chapter gives an overview on one of the oldest, but still indispensable corneal refractive laser surgery strategy, surface ablation (SA), which pioneered the field of laser-refractive-surgery more then 30 years ago.
Comparison of Clinical Results between Transepithelial Photorefractive Keratectomy and Brush Photorefractive Keratectomy
Re-epithelialization and visual recovery were faster in the trans PRK group while visual outcome and postoperative complications were equivalent to the brushPRK group.
Corneal Epithelial Removal with a Newly Designed Epithelial Brush
The newly developed epithelial brush showed better polishing ability and led to earlier significant epithelial recovery and a more regular and uniform stromal surface than conventional methods in this rabbit model of epithelial defects.
Does Mitomycin C Cause Toxicity in the Cornea After Photorefractive Keratectomy? A Comparative Wound-Healing Study in a Refractive Surgery Animal Model
Topical application of MMC in hen corneas reproduces the wound healing observed in humans by reducing haze, keratocyte proliferation, myofibroblast differentiation, and new collagen deposition.
Analysis of ethanol effects on corneal epithelium.
It is suggested that brief exposure of the corneal surface to ethanol may have long-term effects by disrupting the integrity of Corneal epithelium and generating inflammation, both of which are precursors to a number of ocular surface diseases.
Demographic correlations for 100 most-cited authors in ophthalmic research; a bibliometric study
Among highly-cited ophthalmologists, practicing in the US and attending a top medical school or residency program may provide training for a successful research career in ophthalmology.


Mechanical vs. alcohol epithelial removal during photorefractive keratectomy.
Eithelial debridement using a 20% alcohol solution was faster to perform, and provided sharper edges and a smoother Bowman's layer surface than mechanical debridements, which may explain the better results in terms of haze and corneal regularity.
Wound healing anomalies after excimer laser photorefractive keratectomy: correlation of clinical outcomes, corneal topography, and confocal microscopy.
  • R. Steinert
  • Medicine
    Transactions of the American Ophthalmological Society
  • 1997
Vision and predictability are reduced by anomalies 1 month post-PRK but anomalies often resolve by 6 months, and Marked improvement of vision occurs even when anomalies persist.
Clinical results of excimer laser photorefractive keratectomy: a multicenter study of 265 eyes.