Alcohol suppresses the granulopoietic response to pulmonary Streptococcus pneumoniae infection with enhancement of STAT3 signaling.

@article{Siggins2011AlcoholST,
  title={Alcohol suppresses the granulopoietic response to pulmonary Streptococcus pneumoniae infection with enhancement of STAT3 signaling.},
  author={Robert W. Siggins and John Nicholas Melvan and D. J. A. Welsh and Gregory J. Bagby and Steve Nelson and Ping Zhang},
  journal={Journal of immunology},
  year={2011},
  volume={186 7},
  pages={4306-13}
}
Enhanced granulopoietic activity is crucial for host defense against bacterial pneumonia. Alcohol impairs this response. The underlying mechanisms remain obscure. G-CSF produced by infected lung tissue plays a key role in stimulating bone marrow granulopoiesis. This study investigated the effects of alcohol on G-CSF signaling in the regulation of marrow myeloid progenitor cell proliferation in mice with Streptococcus pneumoniae pneumonia. Chronic alcohol consumption plus acute alcohol… CONTINUE READING
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