Alcohol sensitivity in Drosophila: translational potential of systems genetics.

  title={Alcohol sensitivity in Drosophila: translational potential of systems genetics.},
  author={Tatiana V. Morozova and Julien F. Ayroles and Katherine W Jordan and Laura H. Duncan and Mary Anna Carbone and Richard F. Lyman and Eric A. Stone and Diddahally R. Govindaraju and Robert Curtis Ellison and Trudy F C Mackay and Robert R. H. Anholt},
  volume={183 2},
  pages={733-45, 1SI-12SI}
Identification of risk alleles for human behavioral disorders through genomewide association studies (GWAS) has been hampered by a daunting multiple testing problem. This problem can be circumvented for some phenotypes by combining genomewide studies in model organisms with subsequent candidate gene association analyses in human populations. Here, we characterized genetic networks that underlie the response to ethanol exposure in Drosophila melanogaster by measuring ethanol knockdown time in 40… CONTINUE READING
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