Alcohol self-administration: role of mesolimbic dopamine.

  title={Alcohol self-administration: role of mesolimbic dopamine.},
  author={Herman H. Samson and G A Tolliver and Masashi Haraguchi and Clyde W Hodge},
  journal={Annals of the New York Academy of Sciences},
It appears clear that ethanol reinforcement, like that of many abused drugs, utilizes the mesolimbic DA pathways. From the data presented on microinjection of DA agonists and antagonists, it would seem that only part of the regulatory process controlling ethanol drinking is directly involved with this pathway. Once drinking has begun, the DA antagonist raclopride results in a rapid termination of drinking. This appears to be a blocking effect of what may be conditioned reinforcement resulting… CONTINUE READING

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