Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics.


Aldehyde dehydrogenase-2 (ALDH2) eliminates most of the acetaldehyde produced during alcohol metabolism. In some drinkers, a mutant ALDH2 allele contributes to diminished activity of the enzyme, dramatically increasing the risk for esophageal cancer. This study was designed to evaluate the ALDH2 gene polymorphism as a predictor of the development of cancers… (More)


  • Blog articles referencing this paper

  • Presentations referencing similar topics