Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics.

@article{Yokoyama1998AlcoholrelatedCA,
  title={Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics.},
  author={Akira Yokoyama and Taro Muramatsu and Tomohiro Ohmori and Takuhei Yokoyama and Kazuaki Okuyama and Hisao Takahashi and Yoshinori Hasegawa and Susumu Higuchi and Katsuya Maruyama and Katsuyuki Shirakura and Hiromasa Ishii},
  journal={Carcinogenesis},
  year={1998},
  volume={19 8},
  pages={
          1383-7
        }
}
Aldehyde dehydrogenase-2 (ALDH2) eliminates most of the acetaldehyde produced during alcohol metabolism. In some drinkers, a mutant ALDH2 allele contributes to diminished activity of the enzyme, dramatically increasing the risk for esophageal cancer. This study was designed to evaluate the ALDH2 gene polymorphism as a predictor of the development of cancers prevalent in Japanese alcoholics. We performed ALDH2 genotyping on lymphocyte DNA samples from Japanese alcoholic men (487 cancer-free; 237… CONTINUE READING

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