Alcohol-induced state-dependent learning in non-alcoholics.

  title={Alcohol-induced state-dependent learning in non-alcoholics.},
  author={James J. Hinrichsen and Martin Katahn and Robert W Levenson},
  journal={Pharmacology, biochemistry, and behavior},
  volume={2 3},
Abstract The generality of the dissociative effects of a high dosage (1.40 g/kg) of rapidly ingested ethyl alcohol in non-alcoholic human subjects was examined. Verbal memory was found to be more susceptible to dissociation than either motor-skills learning or autonomic (heart-rate) control training. The dissociation of the verbal material appeared to be asymmetrical in that subjects who originally learned the material while intoxicated but were tested 48 hr later while sober showed a greater… Expand
Clinical implications of state-dependent learning.
The authors point out that awareness of changes in cognitive processing strategies and abilities should help to further the understanding of the phenomenology of psychiatric states and should generate psychotherapeutic techniques designed to maximize the transfer of information across psychiatric states. Expand
Effects of alcohol on the storage and retrieval processes of heavy social drinkers.
In both studies, intoxication produced a performance deficit, but retention loss on Day 2 was the same for change- and constant-state subjects, and Expectation had no effect on performance. Expand
Neurobiological correlates of state-dependent context fear.
It is shown that gaboxadol induces profound changes of local and network oscillatory activity, indicative of discoordinated hippocampal-cortical activity, that were accompanied by robust and long-lasting state-dependent conditioned fear, suggesting that continued dependence on hippocampal rather than cortical mechanisms could be an important feature of state- dependent memories that contributes to their conditional retrieval. Expand
Using New Approaches in Neurobiology to Rethink Stress-Induced Amnesia
  • J. Radulovic
  • Psychology, Medicine
  • Current Behavioral Neuroscience Reports
  • 2017
Recent advances in the neurobiology of memory are highlighted that allow us to isolate and visualize memory circuits, change their activity using genetic tools and state-dependent manipulations, and directly examine their impact on socio-affective circuits and global network connectivity. Expand
The cue-dependent nature of state-dependent retrieval
  • J. Eich
  • Psychology, Medicine
  • Memory & cognition
  • 1980
The message of this article is that the unpredictability of state-dependent effects in man is more apparent than real and failures to demonstrate state dependence are restricted to situations in which utilization of stored information is tested in the presence of discretely identifiable retrieval cues. Expand
Altered states of consciousness, state-dependent learning and patient education. An hypothesis of interference.


Alcohol and Recall: State-Dependent Effects in Man
Alcohol appears to produce "dissociated" or state-dependent effects in man, but not all forms of memory are equally sensitive to the phenomenon. Expand
The effects of alcohol on serial verbal learning in chronic alcoholics
Forty male chronic alcoholics, 40–50 years old, learned a list of 12 two-syllable common nouns under alcohol and no-alcohol conditions. Forty-eight h later, they relearned the same or differentExpand
Alcohol state-dependent learning in man.
Alcoholic and nonalcoholic Ss were tested using verbal learning procedures that included 1) multiple trial free-recall learning of random and related words; 2) multiple trial serial learning; and 3)Expand
Effects of alcohol on conditioned avoidance responding
Analysis of variance of the difference scores between training and testing percent avoidances showed an alcohol effect, as well as an interaction of the alcohol effects in the two situations, which are discussed in relation to the central nervous effects of ethanol. Expand
Dissociate effects of ethyl alcohol
Alcohol was demonstrated to have dissociative properties in a negative transfer task but not in a relearning task. In addition, alcohol was shown to retard the rate of acquisition of new learning.
State-dependent effects of alcohol on autonomic orienting responses
The effects of alcohol and change of state on habituation of the orienting responses of skin potential, finger pulse volume, and heart rate in adult males were studied. State-dependent effects ofExpand
Dissociation of Learning and Meprobamate
The results indicated a decrement in latency and frequency of avoidance response only for Ss trained on the drug and tested without it. Expand
Dissociation and Recovery of a Response Learned under the Influence of Chlorpromazine or Saline
Rats trained in an avoidance response while under the influence of chlorpromazine and then tested after receiving an injection of saline, or trained after receiving injections of saline and testedExpand
State dependent learning in humans.
In the experimental groups, regardless of whether the change was from drug (amphetamine of amobarbital to placebo or from placebo to drug, retrieval was impaired in the second, fourth and sixth session and improved in the third and fifth session. Expand
Learning and drugs
Abstract We carried out this investigation on medical students learning meaningless syllables. A survey was made on 559 students in order to find out how they use psychopharmacals. An experimentalExpand