Alcohol induced hepatic fibrosis: role of acetaldehyde.

  title={Alcohol induced hepatic fibrosis: role of acetaldehyde.},
  author={Tommaso Mello and Elisabetta Ceni and Calogero Surrenti and Andrea Galli},
  journal={Molecular aspects of medicine},
  volume={29 1-2},
Alcohol abuse is one of the major causes of liver fibrosis worldwide. Although the pathogenesis of liver fibrosis is a very complex phenomenon involving different molecular and biological mechanisms, several lines of evidence established that the first ethanol metabolite, acetaldehyde, plays a key role in the onset and maintenance of the fibrogenetic process. This review briefly summarizes the molecular mechanisms underlying acetaldehyde pro-fibrogenic effects. Liver fibrosis represents a… CONTINUE READING
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