Alcohol increases the solubility of anaesthetics in the liver.

@article{Fassoulaki1986AlcoholIT,
  title={Alcohol increases the solubility of anaesthetics in the liver.},
  author={A. Fassoulaki and E. Eger},
  journal={British journal of anaesthesia},
  year={1986},
  volume={58 5},
  pages={
          551-4
        }
}
  • A. Fassoulaki, E. Eger
  • Published 1986
  • Medicine
  • British journal of anaesthesia
  • Liver/gas partition coefficients for isoflurane, enflurane, halothane and methoxyflurane increased two-fold in rats killed 16 h after a single injection of 15% ethanol 7 g kg-1. In contrast, blood/gas and brain/gas partition coefficients did not change. Chronic (21 days) ingestion of ethanol increased liver/gas partition coefficients four-fold, although this increase was largely attributable to nutritional changes rather than to a direct effect of ethanol. Only minimal changes (usually not more… CONTINUE READING

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