Alcohol in excess: CRF1 receptors in the rat and mouse VTA and DRN

  title={Alcohol in excess: CRF1 receptors in the rat and mouse VTA and DRN},
  author={Lara S. Hwa and Joseph F Debold and Klaus A Miczek},
Manipulation of the stress neuropeptide corticotropin-releasing factor (CRF), specifically central antagonism of the type 1 receptors (CRF-R1), effectively reduces alcoholic-like ethanol drinking in rodents. Escalated consumption is largely controlled by neurocircuitry that is important for reward and affect, such as the ventral tegmental area (VTA) and the dorsal raphé nucleus (DRN). The current studies investigated the role of CRF-R1 within the VTA and DRN and their relation to escalated… CONTINUE READING


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