Alcohol in essential tremor and other movement disorders

@article{Mostile2010AlcoholIE,
  title={Alcohol in essential tremor and other movement disorders},
  author={Giovanni Mostile and Joseph Jankovic},
  journal={Movement Disorders},
  year={2010},
  volume={25}
}
Many patients with essential tremor (ET) report transient improvement of symptoms after drinking alcohol. However, the brief duration of action, subsequent rebound, and the risk of developing alcohol addiction make the use of alcohol as a treatment for ET inappropriate. Whether excessive alcohol consumption is a risk for or a consequence of ET has been a subject of some controversy. In this review, we critically examine the mechanism of action of alcohol and its role in ET and other movement… 

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References

SHOWING 1-10 OF 158 REFERENCES

Alcohol consumption of patients with essential tremor

TLDR
The frequency and amount of alcohol intake ofessential tremor patients were found to be largely similar to the drinking habits of a control sample from the general population, indicating that essential tremor does not generally augment alcohol consumption, nor is it a common cause of alcoholism.

Alcoholism secondary to essential tremor.

TLDR
Alcohol transiently improves the shakiness of patients with essential (familial) tremor and it is suggested that secondary alcoholism in patients withessential tremor may be treated or prevented by control of the essential tremor with beta-adrenergic blocking agents.

Alcoholism in essential tremor

TLDR
Patients with essential tremor are not at higher risk of chronic alcoholism than other patients with neurologic disease, and patients with Parkinsonian patients had a significantly lower prevalence of alcohol use.

High alcoholism rate in patients with essential tremor.

TLDR
Patients with essential tremor had a significantly higher frequency of alcohol dependence and abuse than control subjects and also had a much higher rate of positive first-degree family history of alcoholism.

The effect of alcohol on essential tremor

TLDR
It is concluded that, in patients with essential tremor, ethanol acts in a specific fashion on sensitive structures within the central nervous system and has no effect on peripheral tremorogenic mechanisms.

Pharmacologic treatment of essential tremor.

TLDR
Chemodenervation with botulinum toxin type A may be a therapeutic option for selected patients with ET and primidone and propranolol have proven efficacy in ET.

Alcohol and Parkinson disease

A survey of the drinking habits of 125 patients with idiopathic Parkinson disease showed no difference from a control population in the amount of alcohol consumed and only mild effects of alcohol on

Relative Efficacy of Alcohol and Propranolol in Action Tremor

TLDR
It is concluded that the tremorilytic effect of alcohol is neither specific for, nor limited to, essential tremor and is of no value in differentiating various neurological disorders which manifest as action tremor.

Parkinsonism in alcohol withdrawal: A follow‐up study

TLDR
The results suggest that withdrawal‐induced parkinsonism is caused by a completely reversible abnormality in nigrostriatal dopamine transmission, which is unaccompanied by underlying nigral degeneration, as the authors had previously hypothesized.

Antimyoclonic effects of alcohol in progressive myoclonus epilepsy

TLDR
Findings show that alcohol is a potent antimyoclonic agent and in the particular context of PME, occasional alcohol intake may help patients in their social life.
...