Alcohol impairs interferon signaling and enhances full cycle hepatitis C virus JFH-1 infection of human hepatocytes.

@article{Ye2010AlcoholII,
  title={Alcohol impairs interferon signaling and enhances full cycle hepatitis C virus JFH-1 infection of human hepatocytes.},
  author={Li Yun Ye and Shihong Wang and Xu Wang and Yu Zhou and Jieliang Li and Yuri Persidsky and Wen-zhe Ho},
  journal={Drug and alcohol dependence},
  year={2010},
  volume={112 1-2},
  pages={107-16}
}
Alcohol drinking and hepatitis C virus (HCV) infection frequently coexist in patients with chronic liver disease. There is limited information, however, about the impact of alcohol on host cell innate immunity and full cycle replication of HCV. This study investigated whether alcohol impairs the intracellular innate immunity in human hepatocytes, promoting HCV infection and replication. Alcohol treatment of human hepatocytes before, during and after viral infection significantly enhanced full… CONTINUE READING

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