Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists

  title={Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists},
  author={Klaus A Miczek and Subuhee Hussain and Sara P Faccidomo},
One of the critical mechanisms by which alcohol heightens aggression involves forebrain serotonin (5-HT) systems, possibly via actions on 5-HT1A receptors. The present experiments tested the hypothesis that activating 5-HT1A receptors by selective agonists will block the aggression-heightening effects of ethanol. Initially, the selective antagonist WAY 100635 was used to assess whether or not the changes in aggressive behavior after treatment with 8-OH-DPAT and flesinoxan result from action at… CONTINUE READING