Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation.

@article{Liu2009AlcoholEA,
  title={Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation.},
  author={Yunlong Liu and Yokesh Balaraman and Guohua Wang and Kenneth P. Nephew and Feng Chao Zhou},
  journal={Epigenetics},
  year={2009},
  volume={4 7},
  pages={500-11}
}
Alcohol exposure during development can cause variable neurofacial deficit and growth retardation known as fetal alcohol spectrum disorders (FASD). The mechanism underlying FASD is not fully understood. However, alcohol, which is known to affect methyl donor metabolism, may induce aberrant epigenetic changes contributing to FASD. Using a tightly controlled whole-embryo culture, we investigated the effect of alcohol exposure (88mM) at early embryonic neurulation on genome-wide DNA methylation… CONTINUE READING
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