Alcohol directly stimulates epigenetic modifications in hepatic stellate cells.

@article{Page2015AlcoholDS,
  title={Alcohol directly stimulates epigenetic modifications in hepatic stellate cells.},
  author={Agata Page and Pier P. Paoli and Stephen J Hill and Rachel Howarth and Raymond P Wu and S H Kweon and Jeremy Jules French and Steve A. White and Hidekazu Tsukamoto and Derek Mann and Jelena Mann},
  journal={Journal of hepatology},
  year={2015},
  volume={62 2},
  pages={388-97}
}
BACKGROUND & AIMS Alcohol is a primary cause of liver disease and an important co-morbidity factor in other causes of liver disease. A common feature of progressive liver disease is fibrosis, which results from the net deposition of fibril-forming extracellular matrix (ECM). The hepatic stellate cell (HSC) is widely considered to be the major cellular source of fibrotic ECM. We determined if HSCs are responsive to direct stimulation by alcohol. METHODS HSCs undergoing transdifferentiation… CONTINUE READING
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Cellular and molecular gastroenterology and hepatology • 2017

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