Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

@article{Hodskinson2020AlcoholderivedDC,
  title={Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms},
  author={Michael R G Hodskinson and Alice Bolner and K. Sato and A. Kamimae-Lanning and K. Rooijers and M. Witte and M. Mahesh and J. Silhan and Maya Petek and D. Williams and J. Kind and J. Chin and K. Patel and Puck Knipscheer},
  journal={Nature},
  year={2020},
  volume={579},
  pages={603-608}
}
Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption 1 . Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers 1 , 2 . Cells are protected against acetaldehyde-induced damage by DNA crosslink repair, which when impaired causes Fanconi anaemia (FA), a disease resulting in failure to produce blood cells and a predisposition to cancer 3 , 4 . The combined inactivation of acetaldehyde… Expand
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