Alcohol dependence: molecular and behavioral evidence.

@article{Trudell2014AlcoholDM,
  title={Alcohol dependence: molecular and behavioral evidence.},
  author={James R. Trudell and Robert O Messing and Jody Mayfield and R. Adron Harris},
  journal={Trends in pharmacological sciences},
  year={2014},
  volume={35 7},
  pages={317-23}
}
Alcohol dependence is a complex condition with clear genetic factors. Some of the leading candidate genes code for subunits of the inhibitory GABAA and glycine receptors. These and related ion channels are also targets for the acute actions of alcohol, and there is considerable progress in understanding interactions of alcohol with these proteins at the molecular and even atomic levels. X-ray structures of open and closed states of ion channels combined with structural modeling and site… CONTINUE READING

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