Alcohol dehydrogenases: a family of isozymes with differential functions.

  title={Alcohol dehydrogenases: a family of isozymes with differential functions.},
  author={Roger S. Holmes},
  journal={Alcohol and alcoholism (Oxford, Oxfordshire). Supplement},
  • Roger S. Holmes
  • Published 1994 in
    Alcohol and alcoholism (Oxford, Oxfordshire…
Human alcohol dehydrogenases (ADHs) are encoded by at least 7 genes, and comprise at least 5 Classes. The isozymes are differentially distributed in tissues, with most Classes exhibiting highest activity in liver. Class IV (mu or sigma) ADH exhibits high activity in stomach and cornea. Class I ADHs have a wide range of physiological substrates, in addition to ethanol, involving metabolism of the following: bile compounds; testosterone; neurotransmitters; congeners; retinol; peroxidic aldehydes… CONTINUE READING
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