Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism

@article{Hellgren2007AlcoholD2,
  title={Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism},
  author={M. Hellgren and P. Str{\"o}mberg and O. Gallego and S. Martras and J. Farr{\'e}s and B. Persson and X. Parés and J. H{\"o}{\"o}g},
  journal={Cellular and Molecular Life Sciences},
  year={2007},
  volume={64},
  pages={498-505}
}
Abstract.The metabolism of all-trans- and 9-cis-retinol/ retinaldehyde has been investigated with focus on the activities of human, mouse and rat alcohol dehydrogenase 2 (ADH2), an intriguing enzyme with apparently different functions in human and rodents. Kinetic constants were determined with an HPLC method and a structural approach was implemented by in silico substrate dockings. For human ADH2, the determined Km values ranged from 0.05 to 0.3 μM and kcat values from 2.3 to 17.6 min−1, while… Expand
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