Alcohol-containing Mouthwashes and Oral Cancer: A Mechanistic Explanation

@inproceedings{CaldernMontao2018AlcoholcontainingMA,
  title={Alcohol-containing Mouthwashes and Oral Cancer: A Mechanistic Explanation},
  author={Jos{\'e} Manuel Calder{\'o}n-Monta{\~n}o and Julio Jos{\'e} Jim{\'e}nez-Alonso and Emilio Guill{\'e}n-Mancina and Estefan{\'i}a Burgos-Mor{\'o}n and Miguel L{\'o}pez-L{\'a}zaro},
  year={2018}
}
Objective: To provide mechanistic evidence for the epidemiological link between long-term use of alcohol containing mouthwashes and oral cancer. Methods: Human epithelial keratinocytes were exposed for 30 seconds to concentrations of ethanol commonly present in mouthwashes. After a recovery period, cell viability was assessed with the MTT assay. Results: A marked cytotoxic effect was observed for ethanol concentrations of 20% and above. Conclusions: The cytotoxicity of ethanol can explain the… CONTINUE READING

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