Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?

@article{Panza2012AlcoholCI,
  title={Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?},
  author={Francesco Panza and Vincenza Frisardi and Davide Seripa and Giancarlo Logroscino and Andrea Santamato and Bruno Pietro Imbimbo and Emanuele Scafato and Alberto Pilotto and Vincenzo Solfrizzi},
  journal={International Journal of Geriatric Psychiatry},
  year={2012},
  volume={27}
}
Objective: In several longitudinal studies, light‐to‐moderate drinking of alcoholic beverages has been proposed as being protective against the development of age‐related changes in cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin (vascular dementia). However, contrasting findings also exist. 
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126 References

Alcohol consumption and transition of mild cognitive impairment to dementia

The relationship between alcohol consumption and risks for dementia in a cohort of elderly patients with MCI was investigated, finding that alcohol drinking patterns may affect cognitive functions and the effects may accumulate to a significant level at an advanced age.

Alcohol Intake and Risk of Dementia

The association between intake of alcoholic beverages and risk of Alzheimer's disease and dementia associated with stroke (DAS) in a cohort of elderly persons from New York City is examined.

Prevention of dementia.

Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes.

As intervention studies are not feasible in this area, the best evidence comes from an overview of epidemiological studies, suggesting that the protective effects are more likely with wine consumption and the absence of an APOE e4 allele.

Lifestyle-related factors in predementia and dementia syndromes

Results are awaited from large multicenter randomized clinical trials in older persons that may clarify the possible synergy, for example, between moderate exercise, physical activity and healthy Mediterranean diet on cognition in the elderly.

Alcohol consumption, mild cognitive impairment, and progression to dementia

In patients with mild cognitive impairment, up to 1 drink/day of alcohol or wine may decrease the rate of progression to dementia.

Alcohol, dementia and cognitive decline in the elderly: a systematic review.

There is some evidence to suggest that limited alcohol intake in earlier adult life may be protective against incident dementia later, but because of the heterogeneity in the data these findings should be interpreted with caution.

The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease

This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein‐E epsilon 4 allele (APOE ε4), and age of disease onset in a community dwelling…

Mild Cognitive Impairment: Incidence and Risk Factors: Results of the Leipzig Longitudinal Study of the Aged

Information is provided on age‐ and sex‐specific incidence rates of mild cognitive impairment (MCI) and risk factors for incident MCI.

Alcohol consumption and incidence of dementia in a community sample aged 75 years and older.

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