Alcohol-associated rhabdomyolysis: ethanol induction of cytochrome P450 may potentiate myotoxicity.

@article{Riggs1998AlcoholassociatedRE,
  title={Alcohol-associated rhabdomyolysis: ethanol induction of cytochrome P450 may potentiate myotoxicity.},
  author={Jack E. Riggs},
  journal={Clinical neuropharmacology},
  year={1998},
  volume={21 6},
  pages={363-4}
}
An association between alcohol use and episodes of rhabdomyolysis has long been recognized, but never understood. Ethanol is a potent inducer of cytochrome P450. In the presence of cytochrome P450, the metabolism of many drugs includes reactive and toxic intermediates. Accordingly, some alcohol-associated myotoxicity could be related to skeletal muscle cytochrome P450 induction by ethanol leading to the production of toxic metabolites of other compounds that then injure muscle. The recent… CONTINUE READING
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