Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats

@article{Jang2002AlcoholAN,
  title={Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats},
  author={Mi-Hyeon D Jang and Min-Chul Shin and Taeck-Hyun Lee and Young-Pyo Kim and Chang-Ju Kim},
  journal={Neuroscience Letters},
  year={2002},
  volume={329},
  pages={141-144}
}
Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells were reduced by alcohol and nicotine treatment in a… CONTINUE READING
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