Alcohol and congenital heart defects: an experimental study in mice.

@article{Webster1984AlcoholAC,
  title={Alcohol and congenital heart defects: an experimental study in mice.},
  author={William S Webster and Michel A. Germain and Abigail Lipson and David Walsh},
  journal={Cardiovascular research},
  year={1984},
  volume={18 6},
  pages={335-8}
}
Pregnant mice were exposed to a single dose of alcohol (0.03 ml of 25% alcohol X g-1 mouse) or two doses (2 X 0.015 ml of 25% alcohol X g-1 mouse) 4 h apart, by intraperitoneal injection or by gavage, on days 7, 8, 9 or 10 of gestation. The mice were killed on the day before term and the fetuses examined for heart defects. Alcohol exposure on day 8, 9 or 10 of gestation caused a high incidence of ventricular septal defects (60%, 75% and 15% respectively). Defects of both the membranous and… CONTINUE READING

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