Alcohol and Dietary Folate Intake and Promoter CpG Island Methylation in Clear-Cell Renal Cell Cancer

@article{Schouten2016AlcoholAD,
  title={Alcohol and Dietary Folate Intake and Promoter CpG Island Methylation in Clear-Cell Renal Cell Cancer},
  author={L. Schouten and I. Deckers and P. A. van den Brandt and M. Baldewijns and M. van Engeland},
  journal={Nutrition and Cancer},
  year={2016},
  volume={68},
  pages={1097 - 1107}
}
ABSTRACT We investigated whether alcohol and dietary folate intakes were associated with promoter methylation in clear-cell renal cell carcinoma (ccRCC). The Netherlands Cohort Study with a case-cohort design included 120,852 subjects aged 55–69 yr in 1986. Diet was measured with a food-frequency questionnaire. After 20.3 yr of follow-up, paraffin-embedded tumor blocks were collected. Methylation-specific polymerase chain reaction (MSP) was used to analyze promoter methylation of 11 genes… Expand

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