Alcohol and Body Weight in the Albino Rat.


This paper deals with one phase, effect upon body weight, of an experiment designed to test the effects of alcohol, both germinal and somatic, upon the albino rat. The data given cover ten successive generations of alcoholic administration. An introductory paper by HANSON and HANDY (1924) gives in detail the methods employed. Suffice it here to say that: the fume tank method devised by STOCKARD was used in administering the alcohol; treatment was begun in each generation when the animals were twenty days of age and continued until they were one hundred days old, except in the first generation where the treatment continued for a period of one year; the treatment might be described as severe, lasting each day until the animals were unable to stand upon their feet; the general environmental conditions for test and control rats were identical-the alcoholic treatment being the single differential between the two groups; both treated and control animals were the descendants of a single pair of WISTAR INSTITUTE semi-inbred rats (Tyler strain) ; all matings throughout the experiment were sister-by-brother within the litter; the animals were weighed to a tenth of a gram at birth, a t twenty days of age and every ten days thereafter until the last weighing at age one hundred days; all weighings were made by the senior author thereby reducing the personal equation to a minimum. After the first generation which was small in numbers an attempt was made to base each body weight constant upon at least fifty rats. In practice, however, this was not always possible, the number falling below in some cases and rising considerably above in others. It is believed that in the rigid character of the controls, the number of treated generations; the strictly inbred character of the blood-lines, and the total number of animals (1825 at twenty days of age) involved, this experiment may contribute something to the alcohol problem. Table 1 gives the data for the totals of the ten generations of control and test animals. The means are based on large numbers of rats, and these numbers are given to the left of each mean in the table. The data for the males and females are given separately. M&s: In males a t twenty days of age the control mean is only 0.27 of a gram greater than the corresponding mean in the treated. As this

1 Figure or Table

Cite this paper

@article{Hanson2003AlcoholAB, title={Alcohol and Body Weight in the Albino Rat.}, author={Floyd B. Hanson and F N Sholes and Florence M. Heys}, journal={Genetics}, year={2003}, volume={13 2}, pages={121-5} }