Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity

@article{Kamal2020AlcoholUD,
  title={Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity},
  author={Haziq Kamal and G. Tan and S. F. Ibrahim and M. Shaikh and I. Mohamed and R. Mohamed and A. Hamid and A. Ugusman and J. Kumar},
  journal={Frontiers in Cellular Neuroscience},
  year={2020},
  volume={14}
}
Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Prolonged excessive alcohol intake contributes to increased production of reactive oxygen species that triggers neuroimmune response and cellular apoptosis and necrosis via lipid peroxidation, mitochondrial, protein or DNA damage. Long term binge alcohol consumption also upregulates glutamate receptors, glucocorticoids and reduces reuptake of glutamate in the central… Expand

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Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain

References

SHOWING 1-10 OF 245 REFERENCES
Lithium-Mediated Protection Against Ethanol Neurotoxicity
  • Jia Luo
  • Medicine
  • Front. Neurosci.
  • 2010
Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF
Human alcohol-related neuropathology
Neuroimmune Function and the Consequences of Alcohol Exposure
GSK3β in Ethanol Neurotoxicity
  • Jia Luo
  • Biology, Medicine
  • Molecular Neurobiology
  • 2009
Targeting glutamate uptake to treat alcohol use disorders
Mechanisms of neurodegeneration and regeneration in alcoholism.
The Role of Oxidative Stress in Neurodegenerative Diseases
...
1
2
3
4
5
...