Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity

  title={Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity},
  author={Haziq Kamal and Geok Chin Tan and Siti Fatimah Ibrahim and Mohd. Farooq Shaikh and Isa Naina Mohamed and Rashidi Mohamed and Adila A Hamid and Azizah Ugusman and Jaya Kumar},
  journal={Frontiers in Cellular Neuroscience},
  • Haziq Kamal, G. Tan, J. Kumar
  • Published 31 August 2020
  • Biology, Medicine, Chemistry
  • Frontiers in Cellular Neuroscience
Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Prolonged excessive alcohol intake contributes to increased production of reactive oxygen species that triggers neuroimmune response and cellular apoptosis and necrosis via lipid peroxidation, mitochondrial, protein or DNA damage. Long term binge alcohol consumption also upregulates glutamate receptors, glucocorticoids and reduces reuptake of glutamate in the central… 

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