Alcohol Metabolism in Asian-American Men with Genetic Polymorphisms of Aldehyde Dehydrogenase

  title={Alcohol Metabolism in Asian-American Men with Genetic Polymorphisms of Aldehyde Dehydrogenase},
  author={T. Wall and C. Peterson and K. P. Peterson and M. L. Johnson and H. Thomasson and M. Cole and C. Ehlers},
  journal={Annals of Internal Medicine},
  • T. Wall, C. Peterson, +4 authors C. Ehlers
  • Published 1997
  • Medicine
  • Annals of Internal Medicine
  • Epidemiologic studies have found that rates of alcohol use and alcoholism in persons of Asian descent are lower than rates in other ethnic groups. One possible reason is that about half of certain Asians, including Chinese, Japanese, and Korean persons, have a deficiency of the low-Km mitochondrial aldehyde dehydrogenase (ALDH2) isoenzyme, which is responsible for metabolizing acetaldehyde. A deficiency of ALDH2 results from inheritance of the mutant ALDH2*2 allele, a dominant mutation that… CONTINUE READING
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