Alcohol-Medication Interactions: The Acetaldehyde Syndrome

  title={Alcohol-Medication Interactions: The Acetaldehyde Syndrome},
  author={Caroline Ribeiro Borja-Oliveira},
  journal={Journal of Pharmacovigilance},
Medications that inhibit aldehyde dehydrogenase when coadministered with alcohol produce accumulation of acetaldehyde. Acetaldehyde toxic effects are characterized by facial flushing, nausea, vomiting, tachycardia and hypotension, symptoms known as acetaldehyde syndrome, disulfiram-like reactions or antabuse effects. Severe and even fatal outcomes are reported. Besides the aversive drugs used in alcohol dependence disulfiram and cyanamide (carbimide), several other pharmaceutical agents are… 

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