Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies

  title={Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies},
  author={Eunyoung Cho and Stephanie A Smith-Warner and John Ritz and Piet A. van den Brandt and Graham A. Colditz and Aaron R. Folsom and Jo L. Freudenheim and Edward L. Giovannucci and R. Alexandra Goldbohm and Saxon Graham and Lars Holmberg and Dong-Hyun Kim and Nea Malila and Anthony B Miller and Pirjo Pietinen and Thomas E Rohan and Thomas A. Sellers and Frank E. Speizer and Walter C. Willett and Alicja Wolk and David J. Hunter},
  journal={Annals of Internal Medicine},
Context Studies suggest that alcohol consumption increases colorectal cancer risk, but the magnitude of the association and its relationship to type of alcoholic beverage and cancer site are ill defined. Contribution This pooled analysis of 8 observational studies showed a small absolute increase in colorectal cancer risk with alcohol consumption of 30 g/d or greater (equivalent to 150 mL of wine), with the greatest risk among people who consumed 45 g/d or greater. Risk did not differ by… 

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Reducing alcohol consumption may decrease the incidence of colon cancer, especially among those with a family history of colorectal cancer.

Alcohol drinking and colorectal cancer in Japanese: a pooled analysis of results from five cohort studies.

An alcohol-colorectal cancer association seems to be more apparent in Japanese than in Western populations, and whether this difference can be ascribed to genetic or environmental factors needs to be clarified.

Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies.

This meta-analysis provides strong evidence for an association between alcohol drinking of >1 drink/day and colorectal cancer risk.

Alcohol consumption and the risk of colon cancer by family history of colorectal cancer 1 – 4

Higher alcohol consumption was associated with an elevated risk of colon cancer, although the association was significant only for the highest intake category of 30 g/d, with no significant linear trend.

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The overall pattern was not significantly modified by other CRC risk factors and there was no effect heterogeneity by tumor site or stage, providing further evidence that there is a J‐shaped association between alcohol consumption and CRC risk.

Alcohol drinking and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population.

It is concluded that alcohol drinking probably increases the risk of colorectal cancer among the Japanese population, and the association for the colon is probable, whereas that for the rectum is possible.



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Calcium, vitamin C, and dietary fiber are inversely related to colon cancer risk in this cohort, and each of these micronutrients displays statistically significant negative correlation with alcohol intake.

A meta-analysis of alcoholic beverage consumption in relation to risk of colorectal cancer

The magnitude of the association between alcohol consumption and risk of colorectal cancer was small, the findings regarding a causal role of alcohol were inconclusive, and the evidence supporting beverage specificity was not conclusive.

Alcohol consumption and risk of colorectal cancer in a cohort of Finnish men

A role for alcohol in colon carcinogenesis is supported and it is suggested that similar studies should evaluate carefully the effects of lifetime drinking habits and recent abstinence.

A case-control study of alcoholic beverage consumption in relation to risk of cancer of the right colon and rectum in men

Analysis based on community controls provided weaker evidence, consistent with previous findings, that heavy consumption of alcohol five years in the past, and possibly of beer in particular, was associated with moderately increased risk of colorectal cancer.

Tobacco, Alcohol, Coffee, and Caffeine as Risk Factors for Colon Cancer in a Low‐Risk Population

It is hypothesized that low use of these substances is one factor contributing to the low colon cancer incidence in Utah and could help explain the low risk associated for colon cancer with being a member of the Church of Jesus Christ of Latter-day Saints.

Prospective study of alcohol consumption and cancer.

A positive association between consumption of alcohol and rectal cancer was revealed, accounted for primarily by an increased risk in men whose usual monthly consumption of beer was 500 oz (15 liters) or more, as compared with those who did not drink beer.

Case-control study of alcoholic beverages as etiological factors: the Melbourne Colorectal Cancer Study.

Beer was found to be a risk factor for rectal cancer, more marked in males than in females, but the relative risks for females were consistent with those for males, which suggests that the beer effect is separate from that of other alcohol variables and also from dietary variables.

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There was a modest indication that high levels of alcohol consumption (11 or more drinks per week) were associated with increased risk of large bowel cancer and wine consumption was associated inversely with these cancers.

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In this cohort of men consuming a diet high in fat, meat, and fiber and low in vegetables, high calcium intake was associated with lowered risk of colorectal cancer.

Dietary Calcium and Vitamin D Intake and Risk of Colorectal Cancer: A Prospective Cohort Study in Women

The data suggest that high calcium intake may lower colorectal cancer risk, and the inverse association may be strongest in relation to distal cancers and among older women.