Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis inMaleMice throughActivation of the Wnt / b-Catenin Signaling Pathway

Although alcohol effects within the liver have been extensively studied, the complex mechanisms by which alcohol causes liver cancer are not well understood. It has been suggested that ethanol (EtOH) metabolism promotes tumor growth by increasing hepatocyte proliferation. In this study, we developed a mouse model of tumor promotion by chronic EtOH… CONTINUE READING