Alcohol, Neurotransmitter Systems, and Behavior

@article{Chastain2006AlcoholNS,
  title={Alcohol, Neurotransmitter Systems, and Behavior},
  author={Garvin D Chastain},
  journal={The Journal of General Psychology},
  year={2006},
  volume={133},
  pages={329 - 335}
}
  • G. Chastain
  • Published 1 October 2006
  • Psychology
  • The Journal of General Psychology
Alcohol affects several neurotransmitter systems within the brain. In this article, the author describes its effects on 5 major ones: glutamate, gamma-amino-butyric acid (GABA), dopamine, serotonin, and opioid systems. The author also notes the interactions and interdependencies of these transmitters, and provides details on both immediate effects and long-term adaptations. Last, the author explains several psychopharmacological treatments for alcoholism and the effects of these treatments on… 
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References

SHOWING 1-10 OF 24 REFERENCES
The Role of Serotonin in Alcohol's Effects on the Brain
TLDR
Alcoholics and experimental animals that consume large quantities of alcohol show evidence of differences in brain serotonin levels compared with nonalcoholics, and abnormalities in the brain’s serotonin system appear to play an important role in thebrain processes underlying alcohol abuse.
Neurobiology of alcohol abuse.
Endogenous opioid systems and alcohol addiction
  • A. Herz
  • Biology, Medicine
    Psychopharmacology
  • 1997
TLDR
Results obtained in genetic models of high preference for alcohol support the view that alcohol intake depends on the activity of the endogenous opioid reward system and that alcohol consumption may serve to compensate for inherent deficits in this system.
Cellular and molecular neuroscience of alcoholism.
TLDR
Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long- term changes in gene expression in alcoholism.
Alcohol and dopamine.
TLDR
Dopamine-containing neurons in the NAc are activated by motivational stimuli, which encourage a person to perform or repeat a behavior, and this dopamine release may contribute to the rewarding effects of alcohol and may thereby play a role in promoting alcohol consumption.
The role of GABAA receptors in the acute and chronic effects of ethanol
TLDR
It is proposed that alterations in native GABAA receptor subunit assembly could alter the functional properties of these receptors, and post-translational modifications or other post-synaptic mechanisms may also explain changes in GAB AA receptor function.
Use of serotonin selective pharmacotherapy in the treatment of alcohol dependence.
  • H. Pettinati
  • Medicine
    Alcoholism, clinical and experimental research
  • 1996
TLDR
This study presents a review of existing human studies that examine the role of serotonin [5-hydroxytryptamine (5-HT)] selective agents in the treatment of alcohol dependence and concludes that additional studies are needed to determine if treatment with 5-HT selective agents is viable therapeutic option for alcoholism.
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
TLDR
In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission.
Attenuation of some alcohol-induced mood changes and the desire to drink by 5-HT3 receptor blockade: a preliminary study in healthy male volunteers
TLDR
Pretreatment with ondansetron significantly attenuated several of the subjective pleasurable effects of alcohol, and also decreased the subjective desire to drink, consistent with preclinical studies suggesting that the reinforcing properties of alcohol may be attenuated by 5-HT3 receptor blockade.
...
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