Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster

@article{Huang2019AlbumycinAN,
  title={Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster},
  author={Chunshuai Huang and Chunfang Yang and Wenjun Zhang and Yiguang Zhu and Liang Ma and Zhuangjie Fang and Changsheng Zhang},
  journal={The Journal of Antibiotics},
  year={2019},
  volume={72},
  pages={311-315}
}
Heterologous expression of the fluostatin biosynthetic gene cluster from the marine-derived Micromonospora rosaria SCSIO N160 in Streptomyces albus J1074 led to the isolation of a novel isoindolequinone albumycin (1) and a known isoquinolinequinone mansouramycin A (2). The structure of 1 was elucidated on the basis of detailed 1D and 2D NMR spectroscopic analysis. Mansouramycin A (2) is active against methicillin-resistant Staphylococcus aureus ATCC 43300, with a MIC of 8 μg ml−1, while… Expand

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