Albumin thiol oxidation and serum protein carbonyl formation are progressively enhanced with advancing stages of chronic kidney disease

@article{Matsuyama2009AlbuminTO,
  title={Albumin thiol oxidation and serum protein carbonyl formation are progressively enhanced with advancing stages of chronic kidney disease},
  author={Yukie Matsuyama and Hiroyuki Terawaki and Tomoyoshi Terada and Seiichi Era},
  journal={Clinical and Experimental Nephrology},
  year={2009},
  volume={13},
  pages={308-315}
}
BackgroundOxidative stress is enhanced in advanced chronic kidney disease (CKD) patients and recognized as a main contributor to cardiovascular disease. Carbonyl stress is also known to be enhanced in advanced CKD; however the precise relationship between oxidative stress and carbonyl stress is not clear. The aim of this study was to investigate potential relationships between oxidative stress, carbonyl stress, and renal function among predialysis patients with CKD.MethodsA total of 32… 
Protein oxidation in chronic kidney disease.
TLDR
Protein oxidation accelerates the glycation processes and seems to be connected with the chronic inflammatory state detectable in renal failure, although the authors did not observe any significant correlation between PC level and leukocyte activation markers.
Plasma Protein Carbonyls as Biomarkers of Oxidative Stress in Chronic Kidney Disease, Dialysis, and Transplantation
TLDR
This review provides an up-to-date overview on advances concerning the correlation between plasma protein carbonylation in CKD progression and the possibility that haemodialysis, peritoneal dialysis, and kidney transplantation improve plasma PCO levels.
Blood Thiol Redox State in Chronic Kidney Disease
TLDR
The evidence suggests thatprotein thiols, S-thiolated proteins, and the protein thiolation index are promising biomarkers of reversible oxidative stress that could be included in the routine monitoring of CKD and ESRD patients.
Oxidized Albumin as a Mediator of Kidney Disease
TLDR
The evidence supporting the role of overweight- and obesity-induced oxidative stress as a critical factor for the progression of renal disease and cardiovascular morbimortality through albumin oxidation is summarized.
Evaluation of dynamic thiol-disulfide balance in children with stage 3-5 chronic kidney disease
Aim: We aimed to examine dynamic thiol-disulfide balance, an indicator of oxidative stress, in children with stage 3-5 chronic kidney disease (CKD). Material and Methods: Native thiol (Nt), total
Plasma Cysteine/Cystine Reduction Potential Correlates with Plasma Creatinine Levels in Chronic Kidney Disease
TLDR
Plasma Eh(Cyss/2Cys) correlated with increased levels of plasma creatinine, supporting the view that uremia triggers oxidative stress and may be used as a quantitative oxidative stress biomarker in uremic conditions.
Serum Albumin Redox States: More Than Oxidative Stress Biomarker
TLDR
An updated overview of analytical techniques for serum albumin redox state and its association with human health, focusing on recent findings is provided.
Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?
TLDR
In hemodialysis patients, the clinical and prognostic significance of oxidative status is very different from general population, and a strong correlation between oxidative index and blood levels of C-reactive protein is highlighted.
Relationship between Xanthine Oxidoreductase Redox and Oxidative Stress among Chronic Kidney Disease Patients
TLDR
Plasma XOR redox is closely related to HSA redox, particularly reversible oxidation of HSA, which is thought to increase the cardiovascular burden among chronic kidney disease (CKD) patients via oxidative radical production.
The Redox State of Albumin and Serious Cardiovascular Incidence in Hemodialysis Patients
  • H. Terawaki, Y. Takada, T. Hosoya
  • Medicine, Biology
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
  • 2010
TLDR
HSA‐redox is closely related to serious CVD incidence and mortality among HD patients, and shows a significantly lower value in patients with CVD than that without CVD.
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