Albumin stabilizes leukotriene A4.

  title={Albumin stabilizes leukotriene A4.},
  author={Frank A. Fitzpatrick and Douglas R. Morton and Michael A Wynalda},
  journal={The Journal of biological chemistry},
  volume={257 9},
Chemical analysis of intact leukotriene A4 showed that vertebrate albumins prolonged its aqueous half-life. At pH 7.4, leukotriene A4 hydrolyzed by first order reaction kinetics with rate constants inversely proportional to the albumin concentration. The stabilizing effect of albumin varied quantitatively among different species. Certain agents, such as warfarin, that interact with the site I binding region of albumin reversed its stabilizing effect. Sequestration and exposure of leukotriene A4… CONTINUE READING
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