Albumin prevents mitochondrial depolarization and apoptosis elicited by endoplasmic reticulum calcium depletion of neuroblastoma cells.

@article{GallegoSandn2005AlbuminPM,
  title={Albumin prevents mitochondrial depolarization and apoptosis elicited by endoplasmic reticulum calcium depletion of neuroblastoma cells.},
  author={Sonia Gallego-Sand{\'i}n and Jes{\'u}s M. Novalbos and Ar{\'a}nzazu Rosado and Mar{\'i}a F. Cano-Abad and Esperanza Arias and Francisco Abad-Santos and Antonio G Garc{\'i}a},
  journal={European journal of pharmacology},
  year={2005},
  volume={520 1-3},
  pages={1-11}
}
Serum albumin protects against cell death elicited by various cytotoxic agents; however, conflicting views on the protective mechanism still remain. Hence, we have studied the ability of serum albumin to prevent apoptosis of human neuroblastoma SH-SY 5 Y cells elicited by four compounds known to release Ca(2+) from the endoplasmic reticulum, i.e. dotarizine, flunarizine, thapsigargin and cyclopiazonic acid. Spontaneous basal apoptosis, after 24 h incubation in Dulbecco's Modified Eagle Medium… CONTINUE READING

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