Albumin nanoparticles as carriers for a phosphodiester oligonucleotide.

  title={Albumin nanoparticles as carriers for a phosphodiester oligonucleotide.},
  author={Amaia Arnedo and Socorro Espuelas and Juan M Irache},
  journal={International journal of pharmaceutics},
  volume={244 1-2},
The goal of this study was the evaluation of albumin nanoparticles as drug delivery systems for antisense oligonucleotides. Bovine serum albumin (BSA) nanoparticles were prepared by a coacervation process. A phosphodiester oligonucleotide was either incorporated into the matrix of the particles by incubation with the albumin prior the coacervation process or adsorbed onto the pre-formed nanoparticles. Incorporated and/or adsorbed oligonucleotide was estimated by capillary electrophoresis and… CONTINUE READING