Albumin leak across human pulmonary microvascular vs. umbilical vein endothelial cells under septic conditions.

@article{Shelton2006AlbuminLA,
  title={Albumin leak across human pulmonary microvascular vs. umbilical vein endothelial cells under septic conditions.},
  author={Jennifer L Shelton and Lefeng Wang and Gediminas Cepinskas and Martin Sandig and Richard Inculet and David G McCormack and Sanjay V Mehta},
  journal={Microvascular research},
  year={2006},
  volume={71 1},
  pages={40-7}
}
Human pulmonary microvascular endothelial cell (HPMVEC) injury is central to the pathophysiology of human lung injury. However, septic HPMVEC barrier dysfunction and the contribution of neutrophils have not been directly addressed in vitro. Instead, human EC responses are often extrapolated from studies of human umbilical vein EC (HUVEC). We hypothesized that HUVEC was not a good model for investigating HPMVEC barrier function under septic conditions. HPMVEC was isolated from lung tissue… CONTINUE READING
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