Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells.

@article{Wang2003AlbuminexpressingHC,
  title={Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells.},
  author={Xiuli Wang and Shundi Ge and George McNamara and Q C Hao and Gay M. Crooks and Jan A Nolta},
  journal={Blood},
  year={2003},
  volume={101 10},
  pages={4201-8}
}
Rodent bone marrow cells can contribute to liver. If these findings are applicable to humans, marrow stem cells could theoretically be harvested from a patient and used to repair his/her damaged liver. To explore this potential, CD34(+) or highly purified CD34(+)CD38(-)CD7(-) human hematopoietic stem cells from umbilical cord blood and bone marrow were transplanted into immunodeficient mice. One month after transplantation, carbon tetrachloride (CCl(4)) was administered into the mice to induce… CONTINUE READING
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