Albumin endocytosis in OK cells: dependence on actin and microtubules and regulation by protein kinases.

@article{Gekle1997AlbuminEI,
  title={Albumin endocytosis in OK cells: dependence on actin and microtubules and regulation by protein kinases.},
  author={Michael Gekle and Sigrid Mildenberger and Ruth Freudinger and Gerald Schwerdt and Stefan Silbernagl},
  journal={The American journal of physiology},
  year={1997},
  volume={272 5 Pt 2},
  pages={
          F668-77
        }
}
We used proximal tubule-derived opossum kidney (OK) cells to determine the dependence of albumin endocytosis on regulation by protein kinases and on the cytoskeleton. Uptake was observed only across the apical but not the basolateral membrane and exceeded uptake in collecting duct-derived Madin-Darby canine kidney cells 14-fold. Inhibition of endocytosis via clathrin-coated vesicles but not via caveolae abolished uptake. Cytochalasin D reduced uptake to < 5% of control, and inhibition of… CONTINUE READING
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