Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs

@inproceedings{Roopenian2015AlbumindeficientMM,
  title={Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs},
  author={Derry Charles Roopenian and Benjamin E Low and Gregory J. Christianson and Gabriele Proetzel and Thomas J. Sproule and Michael V. Wiles},
  booktitle={mAbs},
  year={2015}
}
Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and distributor of compounds including drugs. In humans, serum albumin exhibits an unusually long half-life mainly due to protection from catabolism by neonatal Fc receptor (FcRn)-mediated recycling. These properties make albumin an attractive courier of… CONTINUE READING