Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells.

@article{Ishola2006AlbuminboundFA,
  title={Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells.},
  author={David A Ishola and Jan Andries Post and Mirjan M van Timmeren and Stephan J. L. Bakker and Roel Goldschmeding and Hein A. Koomans and Branko Braam and Jaap A. Joles},
  journal={Kidney international},
  year={2006},
  volume={70 4},
  pages={724-31}
}
Albumin induces oxidative stress and cytokine production in proximal tubular cells (PTECs). Albumin-bound fatty acids (FAs) enhance tubulopathic effects of albumin in vivo. We proposed that FA aggravation of albumin-induced oxidative stress in PTECs might be involved. We hypothesized that mitochondria could be a source of such stress. Using a fluorescent probe, we compared reactive oxygen species (ROS) production after exposure of PTECs to bovine serum albumin (BSA) alone or loaded with oleic… CONTINUE READING

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