Albumin and fibrinogen synthesis and insulin effect in type 2 diabetic patients with normoalbuminuria.

@article{Tessari2006AlbuminAF,
  title={Albumin and fibrinogen synthesis and insulin effect in type 2 diabetic patients with normoalbuminuria.},
  author={Paolo Tessari and Edward Kiwanuka and Renato Millioni and Monica Vettore and Lucia Puricelli and Michela Zanetti and Antonella Gucciardi and Marina Tosolini and Paola Cogo and Virgilio Paolo Carnielli and Antonio Tiengo and Rocco Barazzoni},
  journal={Diabetes care},
  year={2006},
  volume={29 2},
  pages={323-8}
}
OBJECTIVE Insulin stimulates albumin synthesis but inhibits that of fibrinogen in both type 1 diabetic and healthy subjects. In type 2 diabetes, fibrinogen production is increased both in the postabsorptive state and in response to hyperinsulinemia. No data exist on the rate of albumin synthesis and its response to insulin in type 2 diabetes. RESEARCH DESIGN AND METHODS We measured fractional synthesis rates (FSRs) and absolute synthesis rates (ASRs) of both albumin and fibrinogen in… CONTINUE READING