Albumin activates ERK via EGF receptor in human renal epithelial cells.

  title={Albumin activates ERK via EGF receptor in human renal epithelial cells.},
  author={Heather Naomi Reich and David Tritchler and Andrew M. Herzenberg and Zamaneh Kassiri and Xiaohua Zhou and Wei Gao and James William Scholey},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={16 5},
Emerging clinical and experimental evidence strongly implicates proteinuria in the progression of kidney disease. One pathway involves the activation of NFkappaB by albumin, and it has been demonstrated that the activation of NFkappaB induced by albumin is dependent on mitogen-activated protein kinase ERK1/ERK2. To study the effect of albumin on gene expression, primary human renal tubular cells were exposed in vitro to albumin (1%) for 6 h, and gene expression profiling was performed with the… CONTINUE READING


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