Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.

@article{Peeples2005AlbuminAN,
  title={Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.},
  author={Eric S. Peeples and Lawrence M. Schopfer and Ellen Duysen and Reggie S Spaulding and Troy Voelker and Charles M. Thompson and Oksana Lockridge},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={83 2},
  pages={303-12}
}
The classical laboratory tests for exposure to organophosphorus toxicants (OP) are inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in blood. In a search for new biomarkers of OP exposure, we treated mice with a biotinylated organophosphorus agent, FP-biotin. The biotinylated proteins in muscle were purified by binding to avidin-Sepharose, separated by gel electrophoresis, digested with trypsin, and identified from their fragmentation patterns on a quadrupole… CONTINUE READING

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