Albiglutide, a Long Lasting Glucagon-Like Peptide-1 Analog, Protects the Rat Heart against Ischemia/Reperfusion Injury: Evidence for Improving Cardiac Metabolic Efficiency

@inproceedings{Bao2011AlbiglutideAL,
  title={Albiglutide, a Long Lasting Glucagon-Like Peptide-1 Analog, Protects the Rat Heart against Ischemia/Reperfusion Injury: Evidence for Improving Cardiac Metabolic Efficiency},
  author={Weike Bao and K. Aravindhan and Hasan Alsaid and Thimmaiah P. Chendrimada and Matthew E Szapacs and David R. Citerone and Mark R. Harpel and Robert N. Willette and John J. Lepore and Beat M. Jucker},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND The cardioprotective effects of glucagon-like peptide-1 (GLP-1) and analogs have been previously reported. We tested the hypothesis that albiglutide, a novel long half-life analog of GLP-1, may protect the heart against I/R injury by increasing carbohydrate utilization and improving cardiac energetic efficiency. METHODS/PRINCIPAL FINDINGS Sprague-Dawley rats were treated with albiglutide and subjected to 30 min myocardial ischemia followed by 24 h reperfusion. Left ventricle… CONTINUE READING

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