Albendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism

@article{Furtado2019AlbendazoleRI,
  title={Albendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism},
  author={Luis Fernando Viana Furtado and Pedro Henrique Nascimento Aguiar and Luciana Werneck Zuccherato and Talita Tatiana Guimar{\~a}es Teixeira and William Pereira Alves and Vivian Jordania da Silva and Robin B. Gasser and {\'E}lida M Rabelo},
  journal={Parasitology Research},
  year={2019},
  volume={118},
  pages={837-849}
}
Mass drug administration has been implicated as the major cause of drug resistance in nematodes of ruminants. Single-nucleotide polymorphisms (SNPs) at codons 167, 198, and 200 of the beta-tubulin isotype 1 gene are associated with albendazole resistance mechanisms. Although drug resistance is suspected to occur in nematodes of the same order, at present, there is no evidence of a strong correlation between these canonical SNPs and albendazole resistance in hookworms. In the absence of a… CONTINUE READING
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