Albendazole causes stage-dependent developmental toxicity and is deactivated by a mammalian metabolization system in a modified zebrafish embryotoxicity test.

@article{Mattsson2012AlbendazoleCS,
  title={Albendazole causes stage-dependent developmental toxicity and is deactivated by a mammalian metabolization system in a modified zebrafish embryotoxicity test.},
  author={Anna Mattsson and Erik Uller{\aa}s and Johan D M Patring and Agneta Oskarsson},
  journal={Reproductive toxicology},
  year={2012},
  volume={34 1},
  pages={
          31-42
        }
}
The zebrafish embryotoxicity test has previously been combined with an external metabolic activation system (MAS) to assess developmental toxicity of metabolites produced by maternal metabolism. Due to toxicity of MAS the exposure was limited to one early and short period. We have modified the method and included additional testing time points with extended exposure durations. Using the anthelmintic drug albendazole as a model substance, we demonstrated stage-dependent toxic effects at three… CONTINUE READING